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TM6008

Catalog No. T26281 CAS 945008-17-3

Synonyms: TM 6008, TM-6008

TM6008 is an inhibitor of prolyl hydroxylase that protects against cell death after hypoxia.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

TM6008, CAS 945008-17-3

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

TM6008 is an inhibitor of prolyl hydroxylase that protects against cell death after hypoxia.

Synonyms	TM 6008, TM-6008
Molecular Weight	387.39
Formula	C21H17N5O3
CAS No.	945008-17-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Tada Y, Ogawa M, Watanabe R, Zempo H, Takamura C, Suzuki J, Dan T, Miyata T, Isobe M, Komuro I. Neovascularization induced by hypoxia inducible transcription factor is associated with the improvement of cardiac dysfunction in experimental autoimmune myocarditis. Expert Opin Investig Drugs. 2014 Feb;23(2):149-62. doi: 10.1517/13543784.2014.855196. Epub 2013 Nov 11. PubMed PMID: 24205804. 2. Kontani S, Nagata E, Uesugi T, Moriya Y, Fujii N, Miyata T, Takizawa S. A novel prolyl hydroxylase inhibitor protects against cell death after hypoxia. Neurochem Res. 2013 Dec;38(12):2588-94. doi: 10.1007/s11064-013-1175-0. Epub 2013 Oct 17. PubMed PMID: 24132642; PubMed Central PMCID: PMC3898357. 3. Takizawa S, Nagata E, Luo HR. [Novel neuroprotective agents: a HIF activator and an Akt activator]. Rinsho Shinkeigaku. 2012;52(11):911-2. Japanese. PubMed PMID: 23196464. 4. Takeda K, Ichiki T, Narabayashi E, Inanaga K, Miyazaki R, Hashimoto T, Matsuura H, Ikeda J, Miyata T, Sunagawa K. Inhibition of prolyl hydroxylase domain-containing protein suppressed lipopolysaccharide-induced TNF-alpha expression. Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2132-7. doi: 10.1161/ATVBAHA.109.196071. Epub 2009 Sep 17. PubMed PMID: 19762779.

Dose Conversion

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Molecule Formula

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Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TM6008 945008-17-3 TM 6008 TM-6008 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.