keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TAT-DEF-Elk-1 is a cell-penetrating peptide Elk-1 inhibitor.
Pack Size | Availability | Price/USD | Quantity |
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100 mg | Inquiry | Inquiry | |
500 mg | Inquiry | Inquiry |
Description | TAT-DEF-Elk-1 is a cell-penetrating peptide Elk-1 inhibitor. |
Targets&IC50 | ELK1: |
In vitro | Elk-1 phosphorylation on Ser383/389 has a dual function and triggers both Elk-1 nuclear translocation and SRE-dependent gene expression. TAT-DEF-Elk-1 (5 μM; 2 hours) treatment shows significant inhibition of c-Fos, Zif268, and JunB, but has no effects on c-Jun expression. TAT-DEF-Elk-1 (5-10 μM; 1 hour) specifically inhibits glutamate-induced elk-1 activation and does not interfere with ERK, MSK-1, or CREB phosphorylation [1]. |
In vivo | TAT-DEF-Elk-1 (i.p.; 1mg/kg; daily; 14 days) reflects antidepressant efficacy in mice, it decreases immobility similar to the antidepressant desipramine and fluoxetine [2]. |
Synonyms | TDE |
Molecular Weight | 3561.136 |
Formula | C155H259N57O40 |
CAS No. | 1220751-16-5 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TAT-DEF-Elk-1 1220751-16-5 Others TATDEFElk1 TAT DEF Elk 1 TDE inhibitor inhibit