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Synucleozid hydrochloride (502139-01-7 free base)

Catalog No. T13049L CAS 2741856-68-6

Synonyms: Synucleozid hydrochloride, NSC 377363 hydrochloride

Synucleozid hydrochloride is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson’s disease.

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Synucleozid hydrochloride (502139-01-7 free base) Chemical Structure

Synucleozid hydrochloride (502139-01-7 free base), CAS 2741856-68-6

Pack Size	Availability	Price/USD
5 mg	Inquiry	$ 311.00
10 mg	Inquiry	$ 486.00
50 mg	Inquiry	$ 1,366.00
100 mg	Inquiry	$ 2,466.00

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Biological Description

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Description	Synucleozid hydrochloride is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson’s disease.
Targets&IC50	SNCA IRE RNA:1.5 μM
In vitro	Synucleozid (0.25-1 μM; 24 hours) eliminates α-synuclein preformed fibrils induced cytotoxicity, fibrils act as seeds and recruit endogenous α-synuclein aggregation.Synucleozid (0-1 μM; 24 hours) binds to the A bulge near the base of the IRE hairpin, reduced levels of α-synuclein in a dose-dependent manner(IC50 : 500 nM), and inhibits α-synuclein protein expression in SH-SY5Y neuroblastoma cells.Synucleozid (100 nM-100 μM; 24 hours) binds to 2-AP-labeled and native IRE RNA with similar affinities. It decreases 2-AP emission(EC50?value of 2.7 μM), recovery of 2-AP emissions is observed as a function of unlabeled?SNCA?IRE RNA (RNA-0) concentration, affording a competitive?Kd?of 1.5 μM.Synucleozid (0.25-1 μM; 24 hours) decreases α-synuclein and other proteins that have IREs in their mRNA's UTR including APP, PrP, Ferritin and TfR as a dose-dependent mannner. All panels is completed in SH-SY5Y cells, except for PrP protein which is assessed in Neuro-2A cells.

Synonyms	Synucleozid hydrochloride, NSC 377363 hydrochloride
Molecular Weight	404.9
Formula	C22H21ClN6
CAS No.	2741856-68-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Zhang P, et al. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1457-1467.

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Keywords

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