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Sulfaguanidine

Name: Sulfaguanidine
Brand: TargetMol
SKU: T0510
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0510Cas No. 57-67-0

Alias Sulfaguine, Guanicil

Sulfaguanidine (Guanicil), a sulfonamide, is served as an anti-infective agent.

Sulfaguanidine

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Purity: 97.78%

Catalog No. T0510Alias Sulfaguine, GuanicilCas No. 57-67-0

Sulfaguanidine (Guanicil), a sulfonamide, is served as an anti-infective agent.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$35	In Stock	In Stock
5 g	$78	-	In Stock
10 g	$117	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.78%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Sulfaguanidine (Guanicil), a sulfonamide, is served as an anti-infective agent.
In vitro	Adult rats exhibit a more robust elimination capability for Sulfaguanidine when compared to neonatal rats. Pharmacokinetic studies of gastrointestinal absorption reveal that, following oral administration, the peak plasma concentration in adult rats is significantly lower than that in neonatal rats, although there is no marked difference in the time taken to reach peak blood levels. The absolute bioavailability in adult rats (12.76%) is approximately one-fifth that of neonatal rats (57.86%). In adults, the plasma elimination of Sulfaguanidine, administered intravenously at doses of 2.5 or 25 mg/kg, can be described by a two-compartment open model. Conversely, the plasma concentration profile of Sulfaguanidine, post oral administration of 25 mg/kg, is consistent with a one- or two-compartment open model. Consequently, Sulfaguanidine is less readily absorbed in adult rats, while neonatal rats demonstrate effective absorption.
In vivo	Sulfaguanidine, one of the earliest sulfa drugs employed in the treatment of intestinal infections, effectively inhibits the synthesis of nutritional factors in intestinal bacteria. It also efficiently impedes the growth of Gram-negative enterobacteria.
Synonyms	Sulfaguine, Guanicil

Chemical Properties

Molecular Weight	214.24
Formula	C₇H₁₀N₄O₂S
Cas No.	57-67-0
Smiles	S(NC(=N)N)(=O)(=O)C1=CC=C(N)C=C1
Relative Density.	1.3916 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 55 mg/mL (256.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6677 mL	23.3383 mL	46.6766 mL	233.3831 mL
5 mM	0.9335 mL	4.6677 mL	9.3353 mL	46.6766 mL
10 mM	0.4668 mL	2.3338 mL	4.6677 mL	23.3383 mL
20 mM	0.2334 mL	1.1669 mL	2.3338 mL	11.6692 mL
50 mM	0.0934 mL	0.4668 mL	0.9335 mL	4.6677 mL
100 mM	0.0467 mL	0.2334 mL	0.4668 mL	2.3338 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc