Powder: -20°C for 3 years | In solvent: -80°C for 1 year
StemRegenin 1 is an aryl hydrocarbon receptor signaling antagonist (IC50: 127 nM in CD34+ cells).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | $ 88.00 | |
5 mg | Inquiry | $ 384.00 | |
10 mg | Inquiry | $ 677.00 |
Description | StemRegenin 1 is an aryl hydrocarbon receptor signaling antagonist (IC50: 127 nM in CD34+ cells). |
In vitro | In vitro: In a previous study, the unbiased screen with primary human HSCs identified the StemRegenin 1 (SR1), which could promote the ex-vivo expansion of CD34+ cells. In addition, the culture of HSCs with SR1 resulted in a 50-fold increase in cells expressing CD34. Moreover, the mechanistic studies showed that SR1 acted by antagonizing the AhR [1]. |
In vivo | In vivo: In an animal study, 300 to 30,000 uncultured CB CD34+ cells were transplanted into NSG mice. Results showed that CB CD34+ cells cultured with SR1 led to significant increases in human engraftment in the peripheral blood at 1 week, compared with mice transplanted with 10,000 uncultured cells or the progeny of 10,000 control cells [1]. |
Synonyms | StemRegenin 1 (hydrochloride) (1227633-49-9 free base) |
Molecular Weight | 466 |
Formula | C24H23N5OS·HCl |
CAS No. | T23400 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: ≤5mg/ml
You can also refer to dose conversion for different animals. More
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StemRegenin 1 (hydrochloride) T23400 Others StemRegenin 1 (hydrochloride) (1227633-49-9 free base) 1227633-49-9 1227633-49-9 free base StemRegenin 1 inhibitor inhibit