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Sophoflavescenol

Catalog No. TN2217   CAS 216450-65-6

Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , these effects might contribute to the antitumor activity without severe side effects. Sophoflavescenol exerts notable anti-inflammatory activity by inhibiting nitric oxide generation and tert-butylhydroperoxide-induced ROS generation rather than inhibiting nuclear factor kappa B activation in RAW 264.7 cells.

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Sophoflavescenol Chemical Structure
Sophoflavescenol, CAS 216450-65-6
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Purity: 99.65%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , these effects might contribute to the antitumor activity without severe side effects. Sophoflavescenol exerts notable anti-inflammatory activity by inhibiting nitric oxide generation and tert-butylhydroperoxide-induced ROS generation rather than inhibiting nuclear factor kappa B activation in RAW 264.7 cells.
Targets&IC50 BACE1:10.98 µM, HRAR:0.17 µM , RLAR:0.30 µM, BChE:8.21 µM, AGE:17.89 µg/mL, PDE5:0.013 μM 
In vitro Despite the small effect on human breast adenocarcinoma (MCF-7), Sophoflavescenol showed cytotoxicity against human leukaemia (HL-60), Lewis lung carcinoma (LLC), and human lung adenocarcinoma epithelial (A549) cells. Interestingly, it also exerted potent in vivo antitumor activity by tumor growth inhibition in the LLC tumor model as well as apoptotic activity by caspase-3 activation in HL-60 cells. In addition, it exhibited potent antioxidant activities in 1,1-diphenyl-2-picrylhydrazyl, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radicals and lipid peroxidation assays. Sophoflavescenol exerted notable anti-inflammatory activity by inhibiting nitric oxide generation and tert-butylhydroperoxide-induced ROS generation rather than inhibiting nuclear factor kappa B activation in RAW 264.7 cells[1]
Source
Molecular Weight 368.38
Formula C21H20O6
CAS No. 216450-65-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (54.29 mM)

TargetMolReferences and Literature

1. Anti-tumorigenic activity of sophoflavescenol against Lewis lung carcinoma in vitro and in vivo.Arch Pharm Res. 2011 Dec;34(12):2087-99.

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Keywords

Sophoflavescenol 216450-65-6 Metabolism Neuroscience Others Beta-Secretase BACE AChE PDE AChR inhibit β-Secretase Cholinesterase (ChE) Inhibitor Phosphodiesterase (PDE) Beta-secretase inhibitor

 

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