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CMC-Na (Viscosity:800-1200 mPa.s)

Catalog No. T19232 CAS 9004-32-4

Synonyms: CMC-Na (Viscosity:800-1200 mPa.s)

Sodium carboxymethyl cellulose (CMC-Na) (Viscosity:800-1200 mPa.s) is a water-soluble cellulose, commonly used as a co-solvent in animal experiments, and is essentially non-toxic to animals.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CMC-Na (Viscosity:800-1200 mPa.s) Chemical Structure

CMC-Na (Viscosity:800-1200 mPa.s), CAS 9004-32-4

Pack Size	Availability	Price/USD	Quantity
5 g	In stock	$ 96.00
10 g	In stock	$ 143.00

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Purity: polymer

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Sodium carboxymethyl cellulose (CMC-Na) (Viscosity:800-1200 mPa.s) is a water-soluble cellulose, commonly used as a co-solvent in animal experiments, and is essentially non-toxic to animals.

In vivo

METHODS: To test the antitumor activity in vivo, AMG-510 (30 mg/kg in 0.5% Sodium carboxymethyl cellulose) was administered by gavage once a day for four weeks to Balb/C nude mice harboring the human lung cancer tumor H358.
RESULTS: AMG-510 inhibited the growth of H358 tumor. [1]
METHODS: To test the antitumor activity in vivo, cediranib (5 mg/kg in 5% Sodium carboxymethyl cellulose) was administered by gavage to C57BL/6J mice bearing the mouse colorectal cancer tumor MC38 five times a week for eight days.
RESULTS: Cediranib inhibited MC38 tumor growth. [2]

Synonyms	CMC-Na (Viscosity:800-1200 mPa.s)
Molecular Weight	354.375
Formula	C16H27NaO7
CAS No.	9004-32-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: insoluble

References and Literature

1. Wu LL, et al. AMG-510 and cisplatin combination increases antitumor effect in lung adenocarcinoma with mutation of KRAS G12C: a preclinical and translational research. Discov Oncol. 2023 Jun 7;14(1):91. 2. Zhang J, et al. Cediranib enhances the transcription of MHC-I by upregulating IRF-1. Biochem Pharmacol. 2024 Mar;221:116036.

Citations

1. Wu L L, Jiang W M, Liu Z Y, et al.AMG-510 and cisplatin combination increases antitumor effect in lung adenocarcinoma with mutation of KRAS G12C: a preclinical and translational research.Discover Oncology.2023, 14(1): 91. 2. Lan H, Dong Z W, Zhang M Y, et al.Sinapic acid modulates oxidative stress and metabolic disturbances to attenuate ovarian fibrosis in letrozole‐induced polycystic ovary syndrome SD rats.Food Science & Nutrition.2024 3. Zhang J, Guo H, Wang L, et al.Cediranib enhances the transcription of MHC-I by upregulating IRF-1.Biochemical Pharmacology.2024: 116036.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CMC-Na (Viscosity:800-1200 mPa.s) 9004-32-4 Others Viscosity:800-1200 mPa.s Sodium carboxymethyl cellulose CMC-Na Sodium carboxymethyl cellulose (Viscosity:800 1200 mPa.s) Sodium carboxymethyl cellulose (Viscosity:8001200 mPa.s) inhibitor inhibit

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