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Small Cardioactive Peptide B SCPB acetate

Catalog No. TP1844L CAS TP1844L

Synonyms: Small Cardioactive Peptide B SCPB acetate(84746-43-0 free base)

Small Cardioactive Peptide B SCPB acetate (Small Cardioactive Peptide B SCPB acetate (84746-43-0 free base)) is a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC50s of 0.1 and 1.0 μM, respectively.

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Small Cardioactive Peptide B SCPB acetate Chemical Structure

Small Cardioactive Peptide B SCPB acetate, CAS TP1844L

Pack Size	Availability	Price/USD
1 mg	In stock	$ 65.00
5 mg	In stock	$ 196.00
10 mg	In stock	$ 307.00
25 mg	In stock	$ 552.00
50 mg	In stock	$ 793.00
100 mg	In stock	$ 1,090.00
500 mg	In stock	$ 2,220.00

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Purity: 99.65%

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Description

In vitro

Small cardioactive peptide B (SCPB) is a neurally active peptide endogenous to Aplysia. Small cardioactive peptide B (SCPB) possesses cardioexcitatory effects in Aplysia and reported a threshold concentration of 0.01 nM for both native and synthetic Small cardioactive peptide B (SCPB) stimulated effects on the isolated heart. Effects of Small Cardioactive Peptide B (SCPB) on the physiology of the isolated heart and gill preparations from the mollusc Aplysia californica were examined. In addition, the effects of Small Cardioactive Peptide B (SCPB) and FMRFamide (Phe-Met-Arg-Phe-NH2) on adenylate cyclase activity are compared in particulate fractions of heart and gill tissues, respectively. Small Cardioactive Peptide B (SCPB) is found to exert dose-dependent, reversible changes in cardiac activity when perfused through the isolated heart. The EC50 values effecting changes in heart rate and force of contraction are 0.03 and 0.3 nM, respectively; minimum concentrations find to effect changes in heart rate and force of contraction are normally 0.001 and 1 pM, respectively. When perfused through the isolated gill, Small Cardioactive Peptide B (SCPB) is found to suppress the gill withdrawal response amplitude with a threshold concentration of 0.01 pM and an EC50 value of 0.03 nM. Suppression of the gill withdrawal response amplitude by Small Cardioactive Peptide B (SCPB)is found to be dose dependent and reversible up to a concentration of 1nM. At higher concentrations, the suppression tended to persist irreversibly. Small Cardioactive Peptide B (SCPB) stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with an EC50 of 0.1 and 1.0μM, respectively[1].

Synonyms	Small Cardioactive Peptide B SCPB acetate(84746-43-0 free base)
Molecular Weight	1201.47
Formula	C54H84N14O13S2
CAS No.	TP1844L

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Cawthorpe DR, et al. The effects of small cardioactive peptide B on the isolated heart and gill of Aplysia californica. Can J Physiol Pharmacol. 1985 Aug;63(8):918-24.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library NO PAINS Compound Library

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Keywords

Small Cardioactive Peptide B SCPB acetate TP1844L Others Small Cardioactive Peptide B SCPB acetate(84746-43-0 free base) Small Cardioactive Peptide B SCPB Acetate inhibitor inhibit

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