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Metabolism Casein Kinase Silmitasertib sodium salt

Silmitasertib sodium salt

Catalog No. T15024   CAS 1309357-15-0
Synonyms: CX-4945 sodium salt

Silmitasertib sodium salt is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).

Silmitasertib sodium salt, CAS 1309357-15-0
Pack Size Availability Price/USD Quantity
5 mg In stock 80.00
10 mg In stock 113.00
50 mg In stock 372.00
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Purity 99.49%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Silmitasertib sodium salt is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).
Targets&IC50 CK2α : ic50 1 nM ,   CK2α' : ic50 1 nM ,   CK2;Autophagy
In vivo Silmitasertib (CX-4945) (25 or 75 mg/kg, p.o.) is well tolerated. It showed robust antitumor activity with concomitant reductions of the mechanism-based biomarker phospho-p21 (T145) in murine xenograft models[1].
Synonyms CX-4945 sodium salt
Purity 99.49%
Molecular Weight 371.75
Formula C19H11ClN3NaO2
CAS No. 1309357-15-0

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

H2O: 16.67 mg/mL (44.84 mM), Need ultrasonic

DMSO: 6 mg/mL (16.13 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Siddiqui-Jain A, et al. CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. Cancer Res. 2010 Dec 15;70(24):10288-98. 2. Kendall JJ, et al. CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin. Oncotarget. 2016 Aug 16;7(33):53191-53203. 3. Buontempo F, et al. Synergistic cytotoxic effects of PS-341 and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB. Oncotarget. 2016 Jan 12;7(2):1323-40. 4. Chon HJ, et al. The casein kinase 2 inhibitor, CX-4945, as an anti-cancer drug in treatment of human hematological malignancies. Front Pharmacol. 2015 Mar 31;6:70.

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.