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Silmitasertib sodium salt

Catalog No. T15024 CAS 1309357-15-0

Synonyms: CX-4945 sodium salt

Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).

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Silmitasertib sodium salt Chemical Structure

Silmitasertib sodium salt, CAS 1309357-15-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 41.00
5 mg	In stock	$ 67.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 186.00
50 mg	In stock	$ 337.00
1 mL * 10 mM (in DMSO)	In stock	$ 74.00

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Purity: 99.49%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).
Targets&IC50	CK2α:1 nM, CK2α':1 nM
In vitro	Silmitasertib induces cytotoxicity and apoptosis, and exerts anti-proliferative effects in hematological tumors by downregulating CK2 expression and suppressing activation of CK2-mediated PI3K/Akt/mTOR signaling pathways[3]. Silmitasertib (CX-4945) resultes in cell-cycle arrest and selectively induces apoptosis in cancer cells relative to normal cells, attenuates PI3K/Akt signalingand. The antiproliferative activity of Silmitasertib is correlated with expression levels of the CK2α catalytic subunit, attenuation of PI3K/Akt signaling[1]. Silmitasertib with PS-341 treatment prevents leukemic cells from engaging a functional UPR in order to buffer the PS-341-mediated proteotoxic stress in ER lumen, and decreases pro-survival ER chaperon BIP/Grp78 expression[2].
In vivo	Silmitasertib (CX-4945), administered at doses of 25 or 75 mg/kg orally, was well tolerated and demonstrated strong antitumor effects alongside significant decreases in the mechanistic biomarker phospho-p21 (T145) in murine xenograft models[1].

Synonyms	CX-4945 sodium salt
Molecular Weight	371.75
Formula	C19H11ClN3NaO2
CAS No.	1309357-15-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 16.67 mg/mL (44.84 mM), Sonication is recommended.

DMSO: 6 mg/mL (16.13 mM), Sonication is recommended.

References and Literature

1. Siddiqui-Jain A, et al. CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. Cancer Res. 2010 Dec 15;70(24):10288-98. 2. Kendall JJ, et al. CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin. Oncotarget. 2016 Aug 16;7(33):53191-53203. 3. Buontempo F, et al. Synergistic cytotoxic effects of PS-341 and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB. Oncotarget. 2016 Jan 12;7(2):1323-40. 4. Chon HJ, et al. The casein kinase 2 inhibitor, CX-4945, as an anti-cancer drug in treatment of human hematological malignancies. Front Pharmacol. 2015 Mar 31;6:70.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Drug Library Kinase Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Endoplasmic Reticulum Stress Compound Library Bioactive Compounds Library Max Stem Cell Differentiation Compound Library Clinical Compound Library

Related Products

Related compounds with same targets

Emodin A-3 hydrochloride PI-828 XL413 TBCA FPFT-2216 Silmitasertib Casein kinase 1δ-IN-7

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Silmitasertib sodium salt 1309357-15-0 Autophagy Metabolism Stem Cells Casein Kinase Silmitasertib CX4945 inhibit CX-4945 sodium salt Inhibitor CX-4945 sodium CX 4945 CX-4945 Silmitasertib sodium inhibitor

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