Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Seladelpar sodium salt (MBX-8025) is an orally active, effective and specific PPARδ agonist with an EC 50 of 2 nM which exhibiting more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 mg | 10-14 weeks | $ 1,619.00 |
Description | Seladelpar sodium salt (MBX-8025) is an orally active, effective and specific PPARδ agonist with an EC 50 of 2 nM which exhibiting more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively. |
Targets&IC50 | PPARδ:2 nM (EC50) |
In vitro | MBX-8025 is an orally active, potent (EC 50 =2 nM), and specific (750-fold and 2500-fold more potent than PPARα or PPARγ receptors, respectively) PPARδ agonist in development as a lipid-altering agent [2] [3]. |
In vivo | In a study involving Wt mice on an atherogenic diet, Seladelpar sodium salt administration led to a significant reduction of approximately 18% in body weight (P<0.05), whereas its impact on foz/foz mice under the same diet was minimal. Additionally, this compound significantly lowered serum alanine aminotransferase (ALT) levels in foz/foz mice (P<0.05) and exhibited a similar, though not significant, effect in Wt mice. Seladelpar sodium salt was effective in normalizing serum cholesterol levels and reducing triglycerides across both mouse genotypes (P<0.05). It also eliminated hepatocyte ballooning (P<0.05) and halved the nonalcoholic fatty liver disease (NAFLD) activity score by approximately 50%. Moreover, the compound notably diminished sirius red-positive areas in foz/foz mice (P<0.05) [4]. |
Synonyms | RWJ-800025 sodium salt, MBX-8025 sodium salt |
Molecular Weight | 466.45 |
Formula | C21H22F3NaO5S |
CAS No. | 2751530-13-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (107.19 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Seladelpar sodium salt 2751530-13-7 Others Seladelpar sodium RWJ-800025 sodium MBX-8025 sodium RWJ-800025 sodium salt MBX-8025 sodium salt inhibitor inhibit