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Seclidemstat mesylate

Catalog No. T39439 CAS 2044953-70-8

Synonyms: SP-2577 mesylate

Seclidemstat mesylate (SP-2577) is a highly effective and reversible inhibitor of KDM1A (LSD1), with a Ki of 31 nM and an IC 50 of 13 nM. It demonstrates significant potential in promoting antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, while also exhibiting inhibitory effects on virus production, viral DNA replication, and late gene expression. Seclidemstat mesylate is a valuable tool for studying Ewing Sarcoma in research settings.

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Seclidemstat mesylate Chemical Structure

Seclidemstat mesylate, CAS 2044953-70-8

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Description	Seclidemstat mesylate (SP-2577) is a highly effective and reversible inhibitor of KDM1A (LSD1), with a Ki of 31 nM and an IC 50 of 13 nM. It demonstrates significant potential in promoting antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, while also exhibiting inhibitory effects on virus production, viral DNA replication, and late gene expression. Seclidemstat mesylate is a valuable tool for studying Ewing Sarcoma in research settings.
Targets&IC50	LSD1:13 nM (IC50), LSD1:31 nM (Ki)
In vitro	Seclidemstat mesylate, over a period of 72 hours, effectively inhibits the proliferation of various tumor cells with mutations in the SWI/SNF complex, achieving an IC50 range of 0.013 to 2.819 μM across multiple cell lines (COV434, BIN67, SCCOHT-1, TOV21G, SKOV3, A427, H522, A549, H1299, G401, G402, HCC15). Additionally, it enhances the expression and activation of endogenous retroviruses (ERVs) and the IFNβ signaling pathway specifically in SCCOHT cell lines (SCCOHT-1, BIN67, and COV434). At a concentration of 3 μM, Seclidemstat mesylate also upregulates PD-L1 expression in the SCCOHT COV 434 pIND 20 BRG1-2.7 cell line.

Synonyms	SP-2577 mesylate
Molecular Weight	547.04
Formula	C21H27ClN4O7S2
CAS No.	2044953-70-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Dai XJ, et al. Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench to Impair LSD1 [published correction appears in J Med Chem. 2021 May 13;64(9):6410-6411]. J Med Chem. 2021;64(5):2466-2488. 2. Soldi R, et al. The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer. PLoS One. 2020;15(7):e0235705. Published 2020 Jul 10.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Seclidemstat mesylate 2044953-70-8 SP2577 Mesylate SP 2577 Mesylate Seclidemstat Mesylate SP-2577 mesylate SP-2577 Mesylate inhibitor inhibit

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