Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. The agent is not a substrate for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant (MDR) tumors. The epothilone class of metabolites was originally isolated from the myxobacterium Solangium cellulosum.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 4,220.00 | |
50 mg | 10-14 weeks | $ 5,580.00 | |
100 mg | 10-14 weeks | $ 7,900.00 |
Description | Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. The agent is not a substrate for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant (MDR) tumors. The epothilone class of metabolites was originally isolated from the myxobacterium Solangium cellulosum. |
Molecular Weight | 543.71 |
Formula | C30H41NO6S |
CAS No. | 305841-29-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Sagopilone 305841-29-6 DE-03757 Sagopilone. DE 03757 ZK-219477 ZK-EPO ZK 219477 ZK219477 DE03757 inhibitor inhibit