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Saccharin 1-methylimidazole

Catalog No. T6974 CAS 482333-74-4

Synonyms: SMI, Saccharin 1-methylimidazole (SMI)

Saccharin 1-methylimidazole (SMI) is a general-purpose activator used for DNA and RNA synthesis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Saccharin 1-methylimidazole Chemical Structure

Saccharin 1-methylimidazole, CAS 482333-74-4

Pack Size	Availability	Price/USD
10 mg	In stock	$ 39.00
25 mg	In stock	$ 80.00
50 mg	In stock	$ 122.00
100 mg	In stock	$ 197.00
200 mg	In stock	$ 258.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Saccharin 1-methylimidazole (SMI) is a general-purpose activator used for DNA and RNA synthesis.
In vitro	Exposure to various concentrations of distinct promoters, including phenobarbital and the calcium and sodium salts of saccharin (22, 23, 25, 29, 38), induces calcium-deprived T51B cells to commence DNA synthesis as swiftly and as efficiently, or nearly as efficiently, as when the extracellular calcium concentration is increased to 1.25 mM.

Synonyms	SMI, Saccharin 1-methylimidazole (SMI)
Molecular Weight	265.29
Formula	C7H5NO3S·C4H6N2
CAS No.	482333-74-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6 mg/mL (22.62 mM)

References and Literature

1. Boynton AL, et al. Stimulation of DNA synthesis in calcium-deprived T51B liver cells by the tumor promoters phenobarbital, saccharin, and 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 1980 Dec;40(12):4541-5.

Related compound libraries

This product is contained In the following compound libraries：

DNA Damage & Repair Compound Library NO PAINS Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Toxic Compound Library Anti-Aging Compound Library Bioactive Compound Library Cell Cycle Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Saccharin 1-methylimidazole 482333-74-4 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis Saccharin 1 methylimidazole Inhibitor inhibit Saccharin 1methylimidazole SMI Saccharin 1-methylimidazole (SMI) inhibitor

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