Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and <10,000 nM, respectively) and ectopic expression of CYP4F11 in SW203668-insensitive H1155 cells results in sensitization to SW203668.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 93.00 | |
5 mg | 35 days | $ 290.00 | |
10 mg | 35 days | $ 533.00 |
Description | SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and >10,000 nM, respectively) and ectopic expression of CYP4F11 in SW203668-insensitive H1155 cells results in sensitization to SW203668. |
In vivo | In vivo, SW203668 reduces tumor growth rate without reducing sebocyte production in the H2122 wild-type and nonobese diabetic severe combined immunodeficiency (NOD-SCID) mouse xenograft models when administered at doses of 20 and 6 mg/kg, respectively. |
Molecular Weight | 503.49 |
Formula | C24H20F3N3O4S |
CAS No. | 2117405-48-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/mL
DMSO: 20 mg/mL
DMF: 20 mg/mL
Ethanol: 20 mg/mL
You can also refer to dose conversion for different animals. More
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SW203668 (trifluoroacetate salt) 2117405-48-6 SW-203668 SW203668 SW-203668 (trifluoroacetate salt) SW 203668 inhibitor inhibit