Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ST4206 is an antagonist of adenosine A2A. For adenosine A2A receptor and adenosine A1 receptor, the Kis values are 12 nM and 197 nM , respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,820.00 | |
50 mg | 8-10 weeks | $ 2,380.00 | |
100 mg | 8-10 weeks | $ 3,100.00 |
Description | ST4206 is an antagonist of adenosine A2A. For adenosine A2A receptor and adenosine A1 receptor, the Kis values are 12 nM and 197 nM , respectively. |
Targets&IC50 | A1 receptor:197 nM(ki), A2A receptor:(ki)12 nM |
In vitro | ST4206 inhibits agonist-induced cAMP accumulation (IC50: 990 nM)[1]. |
In vivo | ST4206, administered orally at doses of 10, 20, and 40 mg/kg, counteracts haloperidol-induced catalepsy and enhances motor activity in mice in a dose-dependent fashion. At dosages of 20 and 40 mg/kg, the compound markedly augments the number of contralateral turns in rats triggered by l-DOPA[1]. Demonstrating oral efficacy at concentrations of 10, 20, and 40 mg/kg, ST4206 effectively mitigates haloperidol-induced catalepsy in mice[2]. |
Molecular Weight | 286.29 |
Formula | C12H14N8O |
CAS No. | 1246018-36-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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ST4206 1246018-36-9 Others ST 4206 ST-4206 inhibitor inhibit