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SST-02

Catalog No. T34707 CAS T34707

Synonyms: SST 02, SST02

SST-02 is a potent cationic lipid for siRNA-Lipid Nanoparticles. SST-02 possesses a simple chemical structure and is synthesized just in one step. SST-02 showed an ID50 of 0.02 mg/kg in the factor VII (FVII) model. Rats administered with 3 mg/kg of SST-02 LNP did not show changes in body weight, blood chemistry, or hematological parameters, while the AST level decreased at a dose of 5 mg/kg. The use of SST-02 avoids a lengthy synthetic route and may thus decrease the future cost of nucleic acid therapeutics.

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SST-02, CAS T34707

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	SST 02, SST02
Molecular Weight	572.02
Formula	C39H73NO
CAS No.	T34707

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Simplifying the Chemical Structure of Cationic Lipids for siRNA-Lipid Nanoparticles Takeshi Kuboyama, Kaori Yagi, Tomoyuki Naoi, Tomohiro Era, Nobuhiro Yagi, Yoshisuke Nakasato, Hayato Yabuuchi, Saori Takahashi, Fumikazu Shinohara, Hiroto Iwai, Ayumi Koubara-Yamada, Kazumasa Hasegawa, and Atsushi Miwa Publication Date (Web): April 12, 2019 (Letter) doi: 10.1021/acsmedchemlett.8b00652

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SST-02 T34707 SST 02 SST02 inhibitor inhibit

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