Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SRX246 has no interaction at V1b and V2 receptors. SRX246 shows negligible binding at 64 other receptors classes, including 35 G-proteincoupled receptors. SRX246 is a potent and CNS-penetrant vasopressin 1a (V1a) receptor antagonist (Ki=0.3 nM for human V1a).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 987.00 | |
50 mg | 8-10 weeks | $ 1,360.00 | |
100 mg | 8-10 weeks | $ 1,860.00 |
Description | SRX246 has no interaction at V1b and V2 receptors. SRX246 shows negligible binding at 64 other receptors classes, including 35 G-proteincoupled receptors. SRX246 is a potent and CNS-penetrant vasopressin 1a (V1a) receptor antagonist (Ki=0.3 nM for human V1a). |
Targets&IC50 | V1a receptor (human):(ki)0.3 nM |
In vivo | SRX246 (2 mg/kg; i.v.) treatment shows that the Cmax, AUC0-∞ and t1/2 values are 953 ng/mL, 1141 ng ?h/mL, and 6.02 hours, respectively, in plasma pharmacokinetics. SRX246 (20 mg/kg; p.o.) administration display that the Cmax, AUC0-∞ and t1/2 values are 98.4 ng/mL, 624 ng ?h/mL and 2.38 hours, respectively [1]. |
Molecular Weight | 703.87 |
Formula | C42H49N5O5 |
CAS No. | 512784-93-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SRX246 512784-93-9 Others SRX-246 SRX 246 inhibitor inhibit