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SRA880 free base

Catalog No. T28851 CAS 187218-90-2

Synonyms: SRA 880, NVPSRA880, NVP SRA880, NVP-SRA880, SRA-880, SRA880

SRA880 is a non-peptide antagonist of somatostatin sst1-receptor. SRA880 displayed significantly lower affinity for the other human recombinant somatostatin receptors ( pK(d) < or = 6.0). SRA880 shows a certain binding affinity to the human dopamine D4 receptors. SRA880 positively modulates release of endogenous SRIF, was found to synergize with imipramine in causing antidepressant-like effects in the tail suspension test.

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SRA880 free base, CAS 187218-90-2

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Biological Description

Chemical Properties

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Description

Synonyms	SRA 880, NVPSRA880, NVP SRA880, NVP-SRA880, SRA-880, SRA880
Molecular Weight	464.56
Formula	C26H32N4O4
CAS No.	187218-90-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Nilsson A, Stroth N, Zhang X, Qi H, Fälth M, Sköld K, Hoyer D, Andrén PE, Svenningsson P. Neuropeptidomics of mouse hypothalamus after imipramine treatment reveal somatostatin as a potential mediator of antidepressant effects. Neuropharmacology. 2012 Jan;62(1):347-57. doi: 10.1016/j.neuropharm.2011.08.004. Epub 2011 Aug 16. PubMed PMID: 21856315. 2. De Bundel D, Aourz N, Kiagiadaki F, Clinckers R, Hoyer D, Kastellakis A, Michotte Y, Thermos K, Smolders I. Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats. Neuroreport. 2010 Mar 10;21(4):254-8. doi: 10.1097/WNR.0b013e3283353a64. PubMed PMID: 20134357. 3. Foong JP, Parry LJ, Gwynne RM, Bornstein JC. 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum. Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G384-94. doi: 10.1152/ajpgi.00438.2009. Epub 2009 Dec 10. PubMed PMID: 20007849; PubMed Central PMCID: PMC2838515. 4. Marazioti A, Pitychoutis PM, Papadopoulou-Daifoti Z, Spyraki C, Thermos K. Activation of somatostatin receptors in the globus pallidus increases rat locomotor activity and dopamine release in the striatum. Psychopharmacology (Berl). 2008 Dec;201(3):413-22. doi: 10.1007/s00213-008-1305-6. Epub 2008 Sep 3. PubMed PMID: 18766330.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SRA880 free base 187218-90-2 NVPSRA-880 SRA 880 NVPSRA880 NVP-SRA-880 NVP SRA880 SRA-880 free base NVP-SRA 880 NVP SRA-880 NVP-SRA880 SRA-880 NVP SRA 880 SRA880 NVPSRA 880 inhibitor inhibit

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