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SR59230A hydrochloride

Catalog No. T13016L CAS 1135278-41-9

SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating antagonist of β3-Adrenergic Receptor(IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively).

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SR59230A hydrochloride, CAS 1135278-41-9

Pack Size	Availability	Price/USD	Quantity
1 mg	5 days	$ 38.00
1 mL * 10 mM (in DMSO)	5 days	$ 120.00

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating antagonist of β3-adrenergic receptor(IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively).
Targets&IC50	β1 receptor:408 nM , β3 receptor:40 nM , β2 receptor:648 nM
In vitro	In Neuro-2A, BE(2)C and SK-N-BE(2) NB cell lines,SR59230A (100 nM-50 μM; 24 hours) is able to reduce cell viability in a dose-dependent manner [3].
In vivo	Slowly developing hyperthermia, reaching a maximum increase of 1.8°C at 130 min post-injection produced by MDMA (20 mg/kg) . SR59230A (0.5 mg/kg) produces a small but significant attenuation of the slowly developing hyperthermia to MDMA. SR59230A (5 mg/kg) reveals a significant and marked early hypothermic reaction to MDMA[4].

Molecular Weight	361.91
Formula	C21H28ClNO2
CAS No.	1135278-41-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Nisoli E, et al. Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes.Mol Pharmacol. 1996 Jan;49(1):7-14. 2. Kanzler SA, et al. Involvement of β3-adrenergic receptors in the control of food intake in rats.Braz J Med Biol Res. 2011 Nov;44(11):1141-7. 3. Bruno G, et al. β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation.Oncogene. 2020 Jan;39(2):368-384. 4. Bexis S, et al. Role of alpha 1- and beta 3-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse. Br J Pharmacol. 2009 Sep;158(1):259-66.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SR59230A hydrochloride 1135278-41-9 Others SR-59230A hydrochloride inhibitor inhibit

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