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SR 1555 (hydrochloride) (1386439-51-5 free base)

Catalog No. T23387 CAS T23387

Synonyms: SR 1555 (hydrochloride)

SR 1555 is a novel RORγ-specific synthetic ligand.

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SR 1555 (hydrochloride) (1386439-51-5 free base) Chemical Structure

SR 1555 (hydrochloride) (1386439-51-5 free base), CAS T23387

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

SR 1555 is a novel RORγ-specific synthetic ligand.

In vitro

In vitro: In a GAL4-NR chimeric co-transfection assay, SR1555 was devoid of LXR, FXR, and RORα activity, but it dose-dependently repressed the activity at RORγ (IC50: ≈ 1.5 μM). In competitive radioligand binding assays, SR1555 bound to RORγ (IC50: 1 μM). SR1555 specifically targeted RORγ and inhibited its transcriptional activity leading to suppression of IL-17 gene expression. EL4 cells treated SR1555 (10 μM) for 24 h inhibited Il17a gene expression by greater than 70%, demonstrating that SR1555 could inhibit the expression of this TH17 mediated cytokine. SR1555 not only inhibited TH17 cell development and function but also increased the frequency of T regulatory cells [1].

Synonyms	SR 1555 (hydrochloride)
Molecular Weight	496.9
Formula	C22H22F6N2O2·HCl
CAS No.	T23387

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: ≤1.6mg/mL

DMSO: 3mg/ml

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SR 1555 (hydrochloride) (1386439-51-5 free base) T23387 Others SR 1555 (hydrochloride) 1386439-51-5 SR 1555 1386439-51-5 free base SR-1555 SR 1555 (hydrochloride) (1386439515 free base) SR 1555 (hydrochloride) (1386439 51 5 free base) SR1555 inhibitor inhibit

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