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SPR206

Catalog No. T12991 CAS T12991

SPR206 is a polymyxin analogue and an important class of antibiotic for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogen.

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SPR206, CAS T12991

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	SPR206 is a polymyxin analogue and an important class of antibiotic for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogen.
Targets&IC50	Pseudomonas aeruginosa Pa14:（MIC）0.125 mg/L , Acinetobacter baumannii (NCTC13301):0.125 mg/L
In vitro	SPR206 exhibits potent antimicrobial effects against Gram-negative bacteria, displaying Minimum Inhibitory Concentration (MIC) values indicating its effectiveness: 8 mg/L for E. coli IHMA558090, 0.125 mg/L for E. coli ATCC 25922 and A. baumannii ATCC 19003, 0.125 mg/L for K. pneumoniae ATCC 13882, 0.25 mg/L for P. aeruginosa ATCC 27853, and 0.06 mg/L for A. baumannii NCTC13424. Additionally, it demonstrates reduced cytotoxicity [1].
In vivo	In lung tissue and in the thigh model,SPR206 (0.125-30 mg/kg; intravenous injection or subcutaneous injection; every 8 hours or every 4 hours; for 16 hours or 24 hours; neutropenic mice) treatment reduces the burden of Pa14 and NCTC13301 [2].

Molecular Weight	1144.75
Formula	C52H82ClN15O12
CAS No.	T12991

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Brown P, et al. Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206. ACS Infect Dis. 2019 Oct 11;5(10):1645-1656. 2. L. Grosser, et al. In Vivo Efficacy of SPR206 in Murine Lung and Thigh Infection Models Caused by Multidrug Resistant Pathogens Pseudomonas aeruginosa and Acinetobacter baumanii. Poster-139 ASM ESCMID 2018 Lisbon, Portugal.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SPR206 T12991 Others SPR 206 SPR-206 inhibitor inhibit

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