Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SNT-207858 free base is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor(IC50 of 22 nM (binding) and 11 nM (function), on the MC-4 receptor).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 6-8 weeks | $ 446.00 | |
25 mg | 6-8 weeks | $ 1,430.00 | |
50 mg | 6-8 weeks | $ 1,860.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | SNT-207858 free base is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor(IC50 of 22 nM (binding) and 11 nM (function), on the MC-4 receptor). |
In vitro | SNT207858 exhibits binding affinity to the MC-4 receptor at 22 nM, demonstrating significant selectivity with a 170-fold preference compared to MC-3 and a 40-fold preference over MC-5. |
In vivo | In mice,the tumor induced weight loss significantly reduced by SNT207858 (30 mg/kg; oral administration; once daily; 15 days). |
Molecular Weight | 616.62 |
Formula | C32H43Cl2N5O3 |
CAS No. | 1104662-66-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (202.72 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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