Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SNT-207707 is a potent, selective and orally active antagonist of melanocortin MC-4 receptor(IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | SNT-207707 is a potent, selective and orally active antagonist of melanocortin MC-4 receptor(IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor). |
Targets&IC50 | MC-4 (binding):8 nM , MC-4 (function):5 nM |
In vitro | SNT-207707 binds to MC-4 receptor with an affinity of 8 nM, and has over 200-fold selectivity vs. MC-3 and MC-5. SNT207858 is a 22 nM MC-4 antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5. |
In vivo | food intake of the mice distinctly increased by SNT-207707(Single subcutaneous injection of 20 mg/kg). Once daily oral administration of both compounds SNT207858 and SNT-207707 starting the day after tumor implantation significantly reduces the tumor induced weight loss. |
Molecular Weight | 550.18 |
Formula | C32H44ClN5O |
CAS No. | 1064662-40-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (454.40 mM)
MEthanol: 250 mg/mL (454.40 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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SNT-207707 1064662-40-3 Others SNT207707 SNT 207707 inhibitor inhibit