Powder: -20°C for 3 years | In solvent: -80°C for 1 year
c-MET degrader. Comprises MET inhibitor foretinib (GSK 1363089) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours in vitro. Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66.7 nM). Also degrades exon-14-deleted c-MET in Hs746T cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 35 days | $ 735.00 |
Description | c-MET degrader. Comprises MET inhibitor foretinib (GSK 1363089) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours in vitro. Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66.7 nM). Also degrades exon-14-deleted c-MET in Hs746T cells. |
Molecular Weight | 1106.25 |
Formula | C58H65F2N7O11S |
CAS No. | 2230821-68-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55.31 mg/mL(50 mM)
You can also refer to dose conversion for different animals. More
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SJF 8240 2230821-68-6 SJF8240 SJF-8240 inhibitor inhibit