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SIS3

Catalog No. T3636    CAS 521984-48-5    Synonyms: SIS3 HCl

SIS3, a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts and inhibits TGF-β2-induced endothelial cell differentiation in iPSCs.

Pack Size Availability Price/USD Quantity
2 mg In stock 71.00
5 mg In stock 102.00
10 mg In stock 194.00
25 mg In stock 366.00
50 mg In stock 658.00
1 mL * 10 mM (in DMSO) In stock 102.00
Bulk Size: Please Quote for Discount Please Quote for Bulk Size
Biological Activity:

Product Description:

SIS3, a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts and inhibits TGF-β2-induced endothelial cell differentiation in iPSCs.

Receptor:

Smad3;

Chemical Information:
Molecular Weight 489.99
Formula C28H27N3O3·HCl
CAS Number 521984-48-5
Solubility

DMSO: 90 mg/mL (183.7 mM)

Ethanol: 23 mg/mL (46.9 mM)

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage store at -80°C
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.
Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Reference
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