Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SID 3712249 is an inhibitor of the biogenesis of microRNA-544 (miR-544).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 48.00 |
Description | SID 3712249 is an inhibitor of the biogenesis of microRNA-544 (miR-544). |
In vitro | MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple-negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantation into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking the production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir. |
Synonyms | MiR-544 Inhibitor 1 |
Molecular Weight | 323.4 |
Formula | C17H21N7 |
CAS No. | 522606-67-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.67 mg/mL (51.55 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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SID 3712249 522606-67-3 Others SID3712249 SID-3712249 MiR-544 Inhibitor 1 inhibitor inhibit