Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SF1126 is a relevant pan and dual first-in-class PI3K/BRD4 inhibitor. SF1126 is an RGDS-conjugated LY294002 prodrug, which is designed to exhibit increased solubility and bind to specific integrins within the tumor compartment.
Pack Size | Availability | Price/USD | Quantity |
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25 mg | Inquiry | $ 1,520.00 |
Description | SF1126 is a relevant pan and dual first-in-class PI3K/BRD4 inhibitor. SF1126 is an RGDS-conjugated LY294002 prodrug, which is designed to exhibit increased solubility and bind to specific integrins within the tumor compartment. |
In vitro | SF1126 (0.5-2.5 μM; pre-30 minutes) and sorafenib shows that combined treatment of SF1126 and sorafenib blocks multiple key enzymes in PI3K/AKT/mTOR and Ras/Raf/MAPK pathway. SF1126 (1-10 μM; 24 hours) causes cell-cycle arrest with a proportional increase in G0-G1 and a decrease in the number of cells in the S-phase in Hep 3B, Hep G2, SK-Hep1, and Huh7 cells. SF1126 (0-6 μM; 48 hours) inhibits Hep3B, HepG2, SK-Hep1, and Huh7 cell proliferation with IC50s of 5.05, 6.89, 3.14, and 2.14 μM, respectively [1]. |
Molecular Weight | 852.84 |
Formula | C39H48N8O14 |
CAS No. | 936487-67-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SF1126 936487-67-1 Others SF-1126 SF 1126 inhibitor inhibit