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SEMBL

Catalog No. T28749 CAS 1443448-82-5

SEMBL, a novel inhibitor of DNA binding of NF-kappaB component p65 in vitro, inhibits NF-kappaB and cellular invasion in ovarian carcinoma ES-2 cells.

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SEMBL, CAS 1443448-82-5

Pack Size	Availability	Price/USD	Quantity
1 mL * 10 mM (in DMSO)	5 days	$ 125.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

SEMBL, a novel inhibitor of DNA binding of NF-kappaB component p65 in vitro, inhibits NF-kappaB and cellular invasion in ovarian carcinoma ES-2 cells.

Molecular Weight	233.22
Formula	C12H11NO4
CAS No.	1443448-82-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Tiwari PC, Pal R. The potential role of neuroinflammation and transcription factors in Parkinson disease. Dialogues Clin Neurosci. 2017 Mar;19(1):71-80. PubMed PMID: 28566949; PubMed Central PMCID: PMC5442366. 2. Mandengue SH, Owona Manga LJ, Lobè-Tanga MY, Assomo-Ndemba PB, Nsongan-Bahebege S, Bika-Lélé C, Ngo Sack F, Njamnshi AK, Etoundi-Ngoa SL. [Burnout syndrome among generalist medical doctors of Douala region (Cameroon): Can physical activities be a protective factor?]. Rev Med Brux. 2017;38(1):10-15. French. PubMed PMID: 28525196. 3. Stassart C, Stipulante S, Zandona R, Gillet A, Ghuysen A. [Psychological impact of out-of-hospital cardiopulmonary resuscitation (CPR) on the witness engaged in gestures of survival]. Rev Med Liege. 2017 May;72(5):236-240. Review. French. PubMed PMID: 28520322. 4. Ludwig EK, Byron CR, Lahmers KK, Santos MP. Frontal and caudal maxillary sinus lipoma in a horse. Can Vet J. 2017 May;58(5):503-507. PubMed PMID: 28487595; PubMed Central PMCID: PMC5394610.

Dose Conversion

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SEMBL 1443448-82-5 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.