Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectively), with antitumor activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 54.00 | |
5 mg | In stock | $ 128.00 | |
10 mg | In stock | $ 213.00 | |
25 mg | In stock | $ 359.00 | |
50 mg | In stock | $ 535.00 | |
100 mg | In stock | $ 763.00 | |
500 mg | In stock | $ 1,550.00 |
Description | SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectively), with antitumor activity. |
Targets&IC50 | CDK9/cycT:1070 nM (IC50), CDK19/CycC:10.4 nM (IC50), CDK8/CycC:4.4 nM (IC50) |
In vitro | SEL120-34A HCl is a selective, ATP-competitive inhibitor of CDK8(IC50 of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively). SEL120-34A HCl is active against a panel of AML cell lines (GI50<1 μM), such as SKNO-1, KG-1, HEL-60, MOLM-16, MV-4-11, OciAML-2, MOLM-6 and OciAML-3 cells, consistent with the effective inhibition range of STAT1 S727 and STAT5 S726. |
In vivo | The growth of tumor in mice bearing MV4-11 cancer cells inhibited by SEL120-34A (30, 60 mg/kg, p.o.), and also arrests the growth of KG-1-derived tumors at 30 mg/kg via oral administration. |
Molecular Weight | 450.6 |
Formula | C15H19Br2ClN4 |
CAS No. | 1609452-30-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.5 mg/mL, sonification is recommended.
You can also refer to dose conversion for different animals. More
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SEL120-34A HCl 1609452-30-3 Cell Cycle/Checkpoint CDK SEL12034A HCl SEL-120-34A HCl Inhibitor SEL120 34A HCl Cyclin dependent kinase inhibit inhibitor