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SEL120-34A HCl

Catalog No. T10744L   CAS 1609452-30-3

SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectively), with antitumor activity.

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SEL120-34A HCl Chemical Structure
SEL120-34A HCl, CAS 1609452-30-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 54.00
5 mg In stock $ 128.00
10 mg In stock $ 213.00
25 mg In stock $ 359.00
50 mg In stock $ 535.00
100 mg In stock $ 763.00
500 mg In stock $ 1,550.00
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Purity: 99.75%
Purity: 99.7%
Purity: 98.13%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectively), with antitumor activity.
Targets&IC50 CDK9/cycT:1070 nM (IC50), CDK19/CycC:10.4 nM (IC50), CDK8/CycC:4.4 nM (IC50)
In vitro SEL120-34A HCl is a selective, ATP-competitive inhibitor of CDK8(IC50 of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively). SEL120-34A HCl is active against a panel of AML cell lines (GI50<1 μM), such as SKNO-1, KG-1, HEL-60, MOLM-16, MV-4-11, OciAML-2, MOLM-6 and OciAML-3 cells, consistent with the effective inhibition range of STAT1 S727 and STAT5 S726.
In vivo The growth of tumor in mice bearing MV4-11 cancer cells inhibited by SEL120-34A (30, 60 mg/kg, p.o.), and also arrests the growth of KG-1-derived tumors at 30 mg/kg via oral administration.
Molecular Weight 450.6
Formula C15H19Br2ClN4
CAS No. 1609452-30-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 62.5 mg/mL, sonification is recommended.

TargetMolReferences and Literature

1. Rzymski T, et al. SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. Oncotarget. 2017 May 16;8(20):33779-33795.

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Keywords

SEL120-34A HCl 1609452-30-3 Cell Cycle/Checkpoint CDK SEL12034A HCl SEL-120-34A HCl Inhibitor SEL120 34A HCl Cyclin dependent kinase inhibit inhibitor

 

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