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SC-435 mesylate

Catalog No. T28700 CAS 289037-67-8

Synonyms: SC-435, SC435, SC 435

SC-435 is an ileal apical sodium co-dependent bile acid transporter (ASBT). SC-435 inhibits plasma cholesterol.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

SC-435 mesylate, CAS 289037-67-8

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 3,170.00
50 mg	10-14 weeks	$ 4,180.00
100 mg	10-14 weeks	$ 5,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

SC-435 is an ileal apical sodium co-dependent bile acid transporter (ASBT). SC-435 inhibits plasma cholesterol.

Synonyms	SC-435, SC435, SC 435
Molecular Weight	722.01
Formula	C37H59N3O7S2
CAS No.	289037-67-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Braun A, Yesilaltay A, Acton S, Broschat KO, Krul ES, Napawan N, Stagliano N, Krieger M. Inhibition of intestinal absorption of cholesterol by ezetimibe or bile acids by SC-435 alters lipoprotein metabolism and extends the lifespan of SR-BI/apoE double knockout mice. Atherosclerosis. 2008 May;198(1):77-84. Epub 2007 Dec 3. PubMed PMID: 18054357; PubMed Central PMCID: PMC2364648. 2. Zhang XM, Dong L, Liu LN, Lei YM. Effect of SC-435 on the gastrointestinal migrating myoelectric complex in guinea pigs. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Oct;30(5):497-503. PubMed PMID: 16320575. 3. West KL, McGrane M, Odom D, Keller B, Fernandez ML. SC-435, an ileal apical sodium-codependent bile acid transporter inhibitor alters mRNA levels and enzyme activities of selected genes involved in hepatic cholesterol and lipoprotein metabolism in guinea pigs. J Nutr Biochem. 2005 Dec;16(12):722-8. Epub 2005 Aug 9. PubMed PMID: 16169202. 4. West KL, Zern TL, Butteiger DN, Keller BT, Fernandez ML. SC-435, an ileal apical sodium co-dependent bile acid transporter (ASBT) inhibitor lowers plasma cholesterol and reduces atherosclerosis in guinea pigs. Atherosclerosis. 2003 Dec;171(2):201-10. PubMed PMID: 14644388.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SC-435 mesylate 289037-67-8 SC435 Mesylate SC-435 SC 435 mesylate SC435 mesylate SC435 SC 435 Mesylate SC-435 Mesylate SC 435 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.