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GPCR/G Protein OX Receptor SB334867

SB334867

Catalog No. T6140   CAS 792173-99-0
Synonyms: SB 334867, SB-334867, SB-334867 free base, SB334867A free base, SB334867A free base, SB-334867 free base, SB-334867 SB 334867

SB-334867 is a selective orexin-1 (OX1) receptor antagonist.

SB334867, CAS 792173-99-0
Pack Size Availability Price/USD Quantity
2 mg In stock 50.00
5 mg In stock 76.00
10 mg In stock 117.00
25 mg In stock 246.00
50 mg In stock 430.00
100 mg In stock 681.00
1 mL * 10 mM (in DMSO) In stock 76.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SB-334867 is a selective orexin-1 (OX1) receptor antagonist.
Targets&IC50 OX1,  
In vitro In CHO-OX1 cells, SB-334867 inhibits the orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses with pKB of 7.27 and 7.23 respectively, without effect on the UTP (3 microM)-induced calcium response. [1]
In vivo In both male and female rats, SB-334867 (30 mg/kg, i.p.) significantly reduces natural and orexin-A-induced food intake. [2] SB-334867 (2 mg/kg, i.v.) blocks the effects of antipsychotic drugs on dopamine neuronal activity in rats. [3] SB-334867 also inhibits the development of morphine analgesic tolerance in rats. [4]
Animal Research
Animal Model: and feSprague–Dawley rats
Synonyms SB 334867 , SB-334867 , SB-334867 free base , SB334867A free base , SB334867A free base , SB-334867 free base , SB-334867 SB 334867
Purity 99.75%
Molecular Weight 319.32
Formula C17H13N5O2
CAS No. 792173-99-0

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 31.9 mg/mL (100 mM)), with gentle warming

Ethanol: 3.2 mg/mL (10 mM)), with gentle warming

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Smart D, et al. Br J Pharmacol. 2001, 132(6), 1179-1182. 2. Haynes AC, et al. Regul Pept. 2000, 96(1-2), 45-51. 3. Rasmussen K, et al. Neuropsychopharmacology. 2007, 32(4), 786-792. 4. Ranjbar-Slamloo Y, et al. Peptides. 2012, 35(1), 56-59.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library

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