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SB 239063

Catalog No. T6976 CAS 193551-21-2

Synonyms: SB239063

SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.

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SB 239063, CAS 193551-21-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 43.00
2 mg	In stock	$ 58.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 162.00
25 mg	In stock	$ 353.00
50 mg	In stock	$ 529.00
100 mg	In stock	$ 767.00
1 mL * 10 mM (in DMSO)	In stock	$ 71.00

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Purity: 99.81%

Purity: 99.73%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.
Targets&IC50	p38β:44 nM, p38α:44 nM
In vitro	SB 239063 potently inhibits IL-1 and TNF-α production in LPS-stimulated human peripheral blood monocytes with IC50 of 120 and 350 nM, respectively. [1] In oxygen-glucose-deprived hippocampal slice cultures, SB239063 strikingly reduces the levels of the pro-inflammatory cytokine IL-1beta, causes cell death after oxygen-glucose deprivation and significantly diminishes microglia activation. [2] In human corneal endothelial cell, SB 239063 inhibits TGF-β(2) and FGF-2-induced cell migration. [4]
In vivo	In both guinea pigs and mice, SB 239063 (10 mg/kg, p.o.) reduces antigen-induced airway eosinophilia. [1] In air- and ozone-exposed C57/BL6 and MKP-1(-/-) mice, SB239063 inhibits bronchial contraction. [3]

Synonyms	SB239063
Molecular Weight	368.4
Formula	C20H21FN4O2
CAS No.	193551-21-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.7 mg/mL (10 mM), Heating is recommended.

References and Literature

1. Underwood DC, et al. J Pharmacol Exp Ther. 2000, 293(1), 281-288. 2. Strassburger M, et al. Eur J Pharmacol. 2008, 592(1-3), 55-61. 3. Li F, et al. Eur Respir J. 2011, 37(4), 933-942. 4. Joko T, et al. Exp Eye Res. 2013, 108, 23-32.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library CNS-Penetrant Compound Library Osteogenesis Compound Library Anti-Liver Cancer Compound Library Orally Active Compound Library Anti-Cancer Compound Library Reprogramming Compound Library Anti-Aging Compound Library Anti-Colorectal Cancer Compound Library

Related Products

Related compounds with same targets

Agrimonolide p38 MAP Kinase Inhibitor Ⅵ (E)-Ferulic acid methyl ester Bakuchiol 4-Hydroxycinnamamide Neflamapimod Dehydroglyasperin D AMG-47a

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SB 239063 193551-21-2 Autophagy MAPK p38 MAPK inhibit SB-239063 SB239063 Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.