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SB 211475

Catalog No. T28675 CAS 146574-43-8

Synonyms: SB-211475, SB211475

SB 211475, a metabolite of carvedilol, is a novel antihypertensive agent and a potent antioxidant.

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SB 211475, CAS 146574-43-8

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

SB 211475, a metabolite of carvedilol, is a novel antihypertensive agent and a potent antioxidant.

Synonyms	SB-211475, SB211475
Molecular Weight	422.47
Formula	C24H26N2O5
CAS No.	146574-43-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Abreu RM, Santos DJ, Moreno AJ. Effects of carvedilol and its analog BM-910228 on mitochondrial function and oxidative stress. J Pharmacol Exp Ther. 2000 Dec;295(3):1022-30. PubMed PMID: 11082437. 2. Gao F, Chen J, Lopez BL, Christopher TA, Gu J, Lysko P, Ruffolo RR Jr, Ohlstein EH, Ma XL, Yue TL. Comparison of bisoprolol and carvedilol cardioprotection in a rabbit ischemia and reperfusion model. Eur J Pharmacol. 2000 Oct 6;406(1):109-16. PubMed PMID: 11011041. 3. Lysko PG, Lysko KA, Webb CL, Feuerstein G, Mason PE, Walter MF, Mason RP. Neuroprotective activities of carvedilol and a hydroxylated derivative: role of membrane biophysical interactions. Biochem Pharmacol. 1998 Dec 15;56(12):1645-56. PubMed PMID: 9973186. 4. Brunvand H, Liu G, Ma XL, Yue TL, Ruffolo RR Jr, Feuerstein GZ. SB 211475, a metabolite of carvedilol, reduces infarct size after myocardial ischemic and reperfusion injury in rabbits. Eur J Pharmacol. 1998 Sep 4;356(2-3):193-8. PubMed PMID: 9774249.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SB 211475 146574-43-8 SB-211475 SB211475 inhibitor inhibit

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