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Rozanolixizumab

Catalog No. T39057 CAS 1584645-37-3

Synonyms: UCB7665

Rozanolixizumab (RYSTIGGO) is a high-affinity humanized immunoglobulin G4 monoclonal antibody targeting Fc receptors (FcRn) in human newborns for the study of pathogenic IgG in autoimmune and alloimmune diseases.

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Rozanolixizumab, CAS 1584645-37-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 289.00
5 mg	In stock	$ 619.00
10 mg	In stock	$ 887.00
25 mg	In stock	$ 1,330.00
50 mg	In stock	$ 1,780.00
100 mg	In stock	$ 2,430.00

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Description	Rozanolixizumab (RYSTIGGO) is a high-affinity humanized immunoglobulin G4 monoclonal antibody targeting Fc receptors (FcRn) in human newborns for the study of pathogenic IgG in autoimmune and alloimmune diseases.
Targets&IC50	MDCK cells:0.98 nM, FcRn (human):23 pM(Kd), FcRn (monkey):25 pM(Kd)
In vitro	Demonstrating similar affinity at both pH 6.0 (Kd 23 pM and 25 pM for human and cynomolgus monkey, respectively) and pH 7.4 (34 pM and 53 pM for human and cynomolgus monkey, respectively), Rozanolixizumab binds to human FcRn and cynomolgus monkey FcRn[1].In a dose-dependent manner, Rozanolixizumab is observed to inhibit the recycling of human IgG by human FcRn-transfected MDCK cells, with an IC50 of 0.41 nM. The recycling of IgG is similarly inhibited in cynomolgus monkey FcRn-transfected MDCK cells (IC50 0.98 nM)[1].Additionally, Rozanolixizumab causes an increase in intracellular IgG AF647[1].
In vivo	Demonstrating non-linear pharmacokinetics indicative of target-mediated drug disposition, intravenous (IV) dosing of rozanolixizumab in cynomolgus monkeys showed that single IV doses (30 mg/kg) reduced plasma IgG concentration by 69% by Day 7 post-administration. Throughout the treatment period of 42 days, daily IV administration of rozanolixizumab (initial 30 mg/kg loading dose; 5 mg/kg daily thereafter) consistently reduced plasma IgG concentrations in all cynomolgus monkeys, maintaining low concentrations[1].

Synonyms	UCB7665
Molecular Weight	N/A
CAS No.	1584645-37-3

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store at low temperature

store at -20°C

References and Literature

1. Smith B, et al. Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration. MAbs. 2018;10(7):1111-1130.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Rozanolixizumab 1584645-37-3 Others UCB7665 UCB 7665 UCB-7665 inhibitor inhibit

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