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Repaglinide D5

Catalog No. T19548 CAS 1217709-85-7

Synonyms: AG-EE 623ZW D5

Repaglinide D5 is deuterium labeled Repaglinide. Repaglinide is an insulin secretagogue for treatment type-2 diabetes mellitus.

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Repaglinide D5, CAS 1217709-85-7

Pack Size	Availability	Price/USD	Quantity
500 μg	35 days	$ 383.00
1 mg	35 days	$ 725.00

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Description

Repaglinide D5 is deuterium labeled Repaglinide. Repaglinide is an insulin secretagogue for treatment type-2 diabetes mellitus.

In vitro

Mouse insulinoma (MIN-6) cells were divided into 3 groups: low glucose, high glucose, and repaglinide 50 nm groups.?Cells and cell culture mediums were collected at different timepoints.?The expression of pericentrin (PCNT), F-actin, and insulin were tested with immunofluorescence and enzyme-linked immunosorbent assay.All glycemic parameters and variability indexes significantly decreased from baseline to 15 weeks, while no significant difference was found between these 2 groups at baseline or at 15 weeks.?Furthermore, there was no significant difference found in fasting insulin and postprandial insulin at baseline and at 15 weeks, while homeostasis model assessment β significantly increased.?The first-phase glucose and insulin secretion of the intravenous glucose tolerance test improved in both groups, especially in the repaglinide group.?Insulin, PCNT, and F-actin expression in MIN-6 cells decreased after 15 minutes of stimulation with repaglinide, while no difference was observed at 2, 6, and 12 hours.?The insulin levels of the cell medium in the repaglinide group remained significantly higher at all timepoints.

Synonyms	AG-EE 623ZW D5
Molecular Weight	457.62
Formula	C27H36N2O4
CAS No.	1217709-85-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Wang LC, et al. Characteristics of repaglinide and its mechanism of action on insulin secretion in patients with newly diagnosed type-2 diabetes mellitus.Medicine (Baltimore). 2018 Sep;97(38):e12476.

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Keywords

Repaglinide D5 1217709-85-7 Others AG-EE 623ZW D5 Repaglinide D-5 inhibitor inhibit

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