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ReN-1869

Catalog No. T28516 CAS 170149-99-2

Synonyms: NNC-05-1869, NNC 05-1869, NNC-051869, ReN 1869

ReN-1869 is a histamine H1 receptor antagonist. ReN 1869 is active against inflammation and neurogenic pain. ReN-1869 produces potent and selective antinociceptive effects on dorsal horn neurons after inflammation and neuropathy.

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ReN-1869, CAS 170149-99-2

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	NNC-05-1869, NNC 05-1869, NNC-051869, ReN 1869
Molecular Weight	361.48
Formula	C24H27NO2
CAS No.	170149-99-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Schaffler K, Seibel K, Thomsen M, Edwards M. Effect of the new H1-antagonist ReN1869 on capsaicin-induced hyperalgesia in human skin/Human phase-I trial using somatosensory evoked potentials induced by a CO2 laser. Arzneimittelforschung. 2004;54(3):187-91. PubMed PMID: 15112866. 2. Suzuki R, Edwards M, Dickenson AH. ReN-1869 [(R)-1-(3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-3-piperi dine carboxylic acid], a novel histamine H1 receptor antagonist, produces potent and selective antinociceptive effects on dorsal horn neurons after inflammation and neuropathy. J Pharmacol Exp Ther. 2004 Jun;309(3):1230-8. PubMed PMID: 14988422. 3. Skrumsager BK, Ingwersen SH, Gerrits M. Safety and pharmacokinetics of ReN1869: a first human dose study in healthy subjects after single-dose administration. J Clin Pharmacol. 2003 Jan;43(1):66-73. PubMed PMID: 12520630. 4. Olsen UB, Eltorp CT, Ingvardsen BK, Jørgensen TK, Lundbaek JA, Thomsen C, Hansen AJ. ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation. Eur J Pharmacol. 2002 Jan 18;435(1):43-57. PubMed PMID: 11790377.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ReN-1869 170149-99-2 NNC-05-1869 NNC 05-1869 ReN1869 NNC051869 NNC-051869 NNC 051869 ReN 1869 inhibitor inhibit

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