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Rapacuronium bromide

Catalog No. T12690 CAS 156137-99-4

Synonyms: Org 9487

Rapacuronium bromide is an allosteric muscarinic acetylcholine receptor (mAChR) modulator.

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Rapacuronium bromide, CAS 156137-99-4

Pack Size	Availability	Price/USD
5 mg	6-8 weeks	$ 347.00
25 mg	6-8 weeks	$ 987.00
50 mg	6-8 weeks	$ 1,320.00
100 mg	6-8 weeks	$ 2,150.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Rapacuronium bromide is an allosteric muscarinic acetylcholine receptor (mAChR) modulator.
In vitro	Rapacuronium accelerates the rate of ACh binding but decreases its affinity under equilibrium conditions.?This results in potentiation of receptor activation at low concentrations of rapacuronium (1 microM) but not at high concentrations (10 microM).?These observations highlight the relevance and necessity of performing physiological tests under non-equilibrium conditions in evaluating the functional effects of allosteric modulators at muscarinic receptors.
In vivo	Time course of the neuromuscular effects of Rapacuronium following the administration of the 2×ED90 doses to rats and guinea-pigs(ED90 of 5953±199 and 187±16 μg/kg in rat and guinea pig, respectively)[2].

Synonyms	Org 9487
Molecular Weight	677.8
Formula	C37H61BrN2O4
CAS No.	156137-99-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (184.42 mM)

References and Literature

1. Jakubík J, et al. Divergence of allosteric effects of Rapacuronium on binding and function of muscarinic receptors. BMC Pharmacol. 2009 Dec 28;9:15. 2. Vizi ES, et al. A new short-acting non-depolarizing muscle relaxant (SZ1677) without cardiovascular side-effects. Acta Anaesthesiol Scand. 2003 Mar;47(3):291-300.

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Keywords

Rapacuronium bromide 156137-99-4 Others Org 9487 Rapacuronium Bromide inhibitor inhibit

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