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RS-246204

Catalog No. T16799 CAS 878451-87-7

RS-246204 is an R-spondin-1 substitute compound. RS-246204 is able to initiate small intestinal organoids without the use of the R-spondin-1 protein.

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RS-246204, CAS 878451-87-7

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,110.00
50 mg	6-8 weeks	$ 1,450.00
100 mg	6-8 weeks	$ 2,280.00
1 mL * 10 mM (in DMSO)	6-8 weeks	$ 365.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	RS-246204 is an R-spondin-1 substitute compound. RS-246204 is able to initiate small intestinal organoids without the use of the R-spondin-1 protein.
In vitro	RS-246204 could promote the initial formation and growth of enteroids in the medium without R-spondin-1. The enteroids grown with RS-246204 had a similar differentiation capacity as well as self-renewal capacity as the enteroids grown with R-spondin-1. The RS-246204-derived enteroids could successfully produce the forskolin-induced swelling and the organoid based epithelial to mesenchymal transition model [1].
In vivo	RS-246204 obviously enhanced BrdU+ cells and body weight in the DSS induced colitis model. RS-246204 activates the R-spondin dependent pathway in Lgr5 stem cells, thereby enhancing proliferation or the anti-apoptotic effect, promoting regeneration of the intestinal epithelium and reducing the disease severity [1].

Molecular Weight	339.37
Formula	C16H13N5O2S
CAS No.	878451-87-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (14.73 mM), Sonication is recommended.

References and Literature

1. Nam MO, et al. Effects of a small molecule R-spondin-1 substitute RS-246204 on a mouse intestinal organoid culture. Oncotarget. 2017 Dec 26;9(5):6356-6368.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RS-246204 878451-87-7 Others RS246204 RS 246204 inhibitor inhibit

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