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RO27-3225 TFA (274682-89-2 free base)

Catalog No. TP2154 CAS TP2154

Synonyms: RO27-3225 TFA

RO27-3225 TFA is a potent and selective agonist of melanocortin 4 receptor (MC4R; EC50: 1 nM and 8 nM for MC4R and MC1R) with neuroprotective and anti-inflammatory effects. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R.

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RO27-3225 TFA (274682-89-2 free base) Chemical Structure

RO27-3225 TFA (274682-89-2 free base), CAS TP2154

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Description	RO27-3225 TFA is a potent and selective agonist of melanocortin 4 receptor (MC4R; EC50: 1 nM and 8 nM for MC4R and MC1R) with neuroprotective and anti-inflammatory effects. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R.
Targets&IC50	MC3R: 675 nM , MC1R: 8 nM , MC5R:5779 nM , MC4R:（EC50）1 nM
In vivo	RO27-3225 could have a protective role against multiple organ failure following the circulatory shock. RO27-3225 (0.012-0.048 mg/kg; i.v.; Wistar rats) treatment reverses haemorrhagic shock, reduces multiple organ damage and improves survival [2].

Synonyms	RO27-3225 TFA
Molecular Weight	898.93
Formula	C41H53F3N12O8
CAS No.	TP2154

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Benoit SC, et al. A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. J Neurosci. 2000 May 1;20(9):3442-8. 2. Giuliani D, et al. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol. 2007 Mar;150(5):595-603. 3. Zhang Y, et al. Effects of RO27-3225 on neurogenesis, PDGFRβ+ cells and neuroinflammation after cerebral infarction. Int Immunopharmacol. 2020 Feb 11;81:106281.

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Keywords

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