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Pregnenolone monosulfate sodium salt

Catalog No. T16574 CAS 1852-38-6

Synonyms: 3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt

Pregnenolone monosulfate sodium salt is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication. Pregnenolone monosulfate sodium salt acts as a signaling-specific inhibitor of the cannabinoid CB1 receptor. Pregnenolone monosulfate sodium salt also inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors.

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Pregnenolone monosulfate sodium salt Chemical Structure

Pregnenolone monosulfate sodium salt, CAS 1852-38-6

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Description	Pregnenolone monosulfate sodium salt is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication. Pregnenolone monosulfate sodium salt acts as a signaling-specific inhibitor of the cannabinoid CB1 receptor. Pregnenolone monosulfate sodium salt also inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors.
In vitro	Pregnenolone likely acts as a signaling-specific negative allosteric modulator binding to a site distinct from that occupied by orthosteric ligands. Pregnenolone does not modify agonist binding but only agonist efficacy. The effect of THC is obviously attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in the paired-pulse ratio induced by THC but does not modify either the amplitude or the decay time of miniature EPSC [1].
In vivo	Administering Pregnenolone (2 and 4mg/kg) prior to each self-administration session effectively reduces WIN 55,212-2 consumption and lowers the break-point in progressive ratio schedules. Moreover, Pregnenolone doses ranging from 2-6 mg/kg inhibit THC-induced food consumption in Wistar rats and C57BL/6N mice, as well as mitigate THC-related memory deficits in mice, without altering these behaviors independently [1].

Synonyms	3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt
Molecular Weight	419.53
Formula	C21H32NaO5S
CAS No.	1852-38-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8. 2. Ducharme N, et al. Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration. Eur J Pharmacol. 2010 Sep 1;641(2-3):128-34.

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Keywords

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