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Polymyxin B1

Catalog No. T12518 CAS 4135-11-9

Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment.

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Polymyxin B1, CAS 4135-11-9

Pack Size	Availability	Price/USD
1 mg	35 days	$ 294.00
5 mg	35 days	$ 1,190.00
10 mg	35 days	$ 1,890.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment.
In vitro	Polymyxin B1 strongly inhibits protein synthesis in yeast, and in E. coli and S. aureus[4].
In vivo	The area under the concentration-time curve for Polymyxins B1 is greater than those of colistins A and B. Colistin A colistin B. The clearance value of Polymyxins B1 is 2.39 mL/min/kg, the plasma protein binding is 82.3%, the elimination half-life is 79.5 min and the AUC0-∞ is 365 mg?min/L.

Molecular Weight	1203.48
Formula	C56H98N16O13
CAS No.	4135-11-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kwa AL, et al. Pharmacokinetics of polymyxin B1 in patients with multidrug-resistant Gram-negative bacterial infections. Diagn Microbiol Infect Dis. 2008 Feb;60(2):163-7. 2. Berglund NA, et al. Interaction of the antimicrobial peptide polymyxin B1 with both membranes of E. coli: a molecular dynamics study. PLoS Comput Biol. 2015 Apr 17;11(4):e1004180. 3. Tam VH, et al. In vitro potency of various polymyxin B components. Antimicrob Agents Chemother. 2011 Sep;55(9):4490-1. 4. Alonso MA, et al. Compounds affecting membranes that inhibit protein synthesis in yeast. Antimicrob Agents Chemother. 1979 Dec;16(6):750-6. 5. Sivanesan S, et al. Pharmacokinetics of the Individual Major Components of Polymyxin B and Colistin in Rats. J Nat Prod. 2017 Jan 27;80(1):225-229.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Polymyxin B1 4135-11-9 Others Polymyxin B-1 inhibitor inhibit

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