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Pinostrobin chalcone

Catalog No. TN2083   CAS 18956-15-5

Pinostrobin chalcone, a chalcone analog isolated from the leguminous plant, Mucuna pruriens, exhibits anticancer activity with an IC50 value of 20.42±2.23 μg/mL against MDA-MB-231 and 22.51±0.42 μg/mL against the HT-29 colon cancer cell line.

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Pinostrobin chalcone Chemical Structure
Pinostrobin chalcone, CAS 18956-15-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 100.00
5 mg In stock $ 241.00
10 mg In stock $ 357.00
25 mg In stock $ 589.00
50 mg In stock $ 858.00
100 mg In stock $ 1,180.00
1 mL * 10 mM (in DMSO) In stock $ 397.00
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Purity: 98.28%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Pinostrobin chalcone, a chalcone analog isolated from the leguminous plant, Mucuna pruriens, exhibits anticancer activity with an IC50 value of 20.42±2.23 μg/mL against MDA-MB-231 and 22.51±0.42 μg/mL against the HT-29 colon cancer cell line.
In vitro Pinostrobin chalcone (30 μM; 3T3-L1 cells) was a more potent inhibitor of triglyceride accumulation than the positive control berberine. Gene expression studies revealed that treatment of 3T3-L1 cells with Pinostrobin chalcone lowers the expression levels of CCAAT/enhancer-binding protein α± and peroxisome proliferator activator γ2 during adipogenesis without affecting cell viability. Treatment of 3T3-L1 cells with Pinostrobin chalcone reduced the expression levels of mRNAs encoding sterol regulatory element-binding protein 1c and several lipogenic enzymes, including fatty acid synthase and stearoyl CoA desaturase-1.[1]
Molecular Weight 270.28
Formula C16H14O4
CAS No. 18956-15-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (333.0 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

TargetMolReferences and Literature

1. Oikawa N, et al. Inhibitory effects of compounds isolated from the dried branches and leaves of murta (Myrceugenia euosma) on lipid accumulation in 3T3-L1 cells. J Nat Med. 2016;70(3):502-509. 2. Mohammed I, et al. Isolation of cardamonin, pinostrobin chalcone from the rhizomes of Boesenbergia rotunda (L.) Mansf. and their cytotoxic effects on H-29 and MDA-MB-231 cancer cell lines. The Natural Products Journal. 2019;9(4):341-348.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Natural Product Library for HTS Bioactive Compound Library Bioactive Compounds Library Max Selected Plant-Sourced Compound Library Anti-Cancer Compound Library

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Keywords

Pinostrobin chalcone 18956-15-5 inhibitor inhibit

 

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