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Phenprocoumon

Name: Phenprocoumon
Brand: TargetMol
SKU: T7636
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7636Cas No. 435-97-2

Phenprocoumon is an antagonist of vitamin K(IC50:1 μM).

Phenprocoumon

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Purity: 97.98%

Catalog No. T7636Cas No. 435-97-2

Phenprocoumon is an antagonist of vitamin K(IC50:1 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$48	In Stock	In Stock
50 mg	$77	In Stock	In Stock
100 mg	$116	In Stock	In Stock
200 mg	$172	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:97.98%

Color:White

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COA HPLC HNMR LCMS

Product Introduction

Phenprocoumon AI Summary

Phenprocoumon demonstrates a moderate partition coefficient (LogP = 3.62), indicating its ability to balance between aqueous and lipid environments. It has a low dissociation constant (pKa = 5.0), suggesting predominant existence in a specific ionization state under certain conditions. The compound exhibits moderate binding affinity to human serum albumin (Log B/F = 2.128) and weak binding to guinea pig atrial homogenate (Log B/F = 0.396). Phenprocoumon is a potential inhibitor of HIV protease with reported Ki values ranging from 0.8 nM to 1000.0 nM, suggesting binding variations under different conditions. It has shown antiviral activity in HIV-1 infected PBMCs with an ED50 of 300.0 μM and inhibited HIV protease in MT-4 cells with an IC50 of 1000.0 nM. The compound exhibits moderate liver toxicity, with hepatotoxicity reported at 6 times the upper limit for ALT or AST serum levels or 1.7 times for alkaline phosphatase. This moderate toxicity was observed in 37% of clinical trials, with acute liver toxicity reported in 18% of cases. Phenprocoumon demonstrates anticoagulant activity by increasing prothrombin time in rats and exhibits drug uptake in the liver. It also inhibits VKORC1 with a Ki value of 200.0 nM. Additionally, it shows modest antiviral activity against SARS-CoV-2 in various cell lines, including HRCE cells and VERO-6 cells, with an IC50 above 20,000 nM. Furthermore, the compound inhibits human HDAC6 activity, showing 16.18% inhibition in an enzymatic assay. It also exhibits significant binding affinity to HIV protease, with a notable Ki value of 0.8 nM, highlighting its potential as an inhibitor for antiviral therapy. Overall, Phenprocoumon displays multiple bioactivities, including enzyme inhibition, antiviral activity, and potential hepatotoxicity, making it a candidate for further investigation in diverse therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Phenprocoumon is an antagonist of vitamin K(IC50:1 μM).
Targets&IC50	Vitamin K:1 μM

Chemical Properties

Molecular Weight	280.32
Formula	C₁₈H₁₆O₃
Cas No.	435-97-2
Smiles	CCC(c1ccccc1)c1c(O)c2ccccc2oc1=O
Relative Density.	1.261g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (445.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (14.27 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5674 mL	17.8368 mL	35.6735 mL	178.3676 mL
5 mM	0.7135 mL	3.5674 mL	7.1347 mL	35.6735 mL
10 mM	0.3567 mL	1.7837 mL	3.5674 mL	17.8368 mL
20 mM	0.1784 mL	0.8918 mL	1.7837 mL	8.9184 mL
50 mM	0.0713 mL	0.3567 mL	0.7135 mL	3.5674 mL
100 mM	0.0357 mL	0.1784 mL	0.3567 mL	1.7837 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc