Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pazinaclone is a non-benzodiazepine (GABAA) partial agonist with sedative and anxiolytic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 142.00 | |
5 mg | In stock | $ 350.00 | |
10 mg | In stock | $ 530.00 | |
25 mg | In stock | $ 859.00 | |
50 mg | In stock | $ 1,180.00 | |
100 mg | In stock | $ 1,590.00 | |
500 mg | In stock | $ 3,190.00 |
Description | Pazinaclone is a non-benzodiazepine (GABAA) partial agonist with sedative and anxiolytic activity. |
In vivo | Pazinaclone (5 mg/kg; oral; rats, mice, hamsters, and guinea pigs) unchanged drug concentration in plasma was highest in mice (AUC; 90 ng/h/ml), followed in decreasing order by guinea pigs (AUC; 41 ng/h/ml), hamsters (AUC; 18 ng/h/ml), and rats (AUC; 17 ng/h/ml). Among rabbits, dogs, and monkeys, the dogs had the highest plasma drug concentrations: AUCs of pazinaclone in dogs and monkeys were 1035 and 458 ng. h/ml, respectively (drug concentration in rabbit plasma was very low). Of the two polymorphs, forms 1 and 2 with particle size of < or = 5 microns, the oral absorption of form 2 in rats was more efficient than that of form 1 at 1000 mg/kg: AUCs of pazinaclone after dosing of form 1 and 2 were 489 and 965 ng.h/ml, respectively.[2] |
Synonyms | A-77000, DN-2327, DN2327, DN 2327, A 77000, A77000 |
Molecular Weight | 478.93 |
Formula | C25H23ClN4O4 |
CAS No. | 103255-66-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Pazinaclone 103255-66-9 Membrane transporter/Ion channel Neuroscience GABA Receptor A-77000 DN-2327 DN2327 DN 2327 A 77000 A77000 inhibitor inhibit