Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PU139 is a novel inhibitor of histone acetyltransferase (HAT).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 56.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 213.00 | |
25 mg | In stock | $ 463.00 | |
50 mg | In stock | $ 668.00 | |
100 mg | In stock | $ 932.00 | |
500 mg | In stock | $ 1,860.00 |
Description | PU139 is a novel inhibitor of histone acetyltransferase (HAT). |
Targets&IC50 | PCAF:9.74 μM (IC50), p300:5.35 μM (IC50), GCN5:8.39 μM (IC50), CBP:2.49 μM (IC50) |
In vitro | PU139 inhibits cell growth with GI50s of <60 μM (A431, A549, A2780, HCT116, HepG2, SW480, U-87 MG and SK-N-SH and MCF7 cells). PU139 (0-100 μM; 24-72 hours) triggers caspase-independent cell death in the neuroblastoma cell line SK-N-SH[1]. |
In vivo | PU139 (25 mg/kg; i.p.) synergizes with Doxorubicin used as a prototypic chemotherapeutic drug in growth inhibition[1]. |
Synonyms | PU 139, PU-139 |
Molecular Weight | 246.26 |
Formula | C12H7FN2OS |
CAS No. | 158093-65-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (40.61 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PU139 158093-65-3 Chromatin/Epigenetic Histone Acetyltransferase PU 139 PU-139 inhibitor inhibit