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PKC ζ pseudosubstrate

Catalog No. TP1956 CAS TP1956

Inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by a disulphide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide. Induces mast cell degranulation by a PKC ζ-independent pathway.

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PKC ζ pseudosubstrate Chemical Structure

PKC ζ pseudosubstrate, CAS TP1956

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1 mg	Inquiry	$ 350.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	4673.59
Formula	C208H336N74O44S3
CAS No.	TP1956

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 2 mg/mL

References and Literature

1. Laudanna et al (1998) Evidence of ζ protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. J.Biol.Chem 273 30306 PMID: 2. Lim et al (2008) A myristoylated pseudosubstrate peptide of PKC-ζ induces degranulation in HMC-1 cells independently of PKC-ζ activity. Life Sci. 82 733 PMID: 3. Theodore et al (1995) Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 15 7158 PMID:

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Keywords

PKC ζ pseudosubstrate TP1956 inhibitor inhibit

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