Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PGS-IN-1 (KME-4) is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 197.00 | |
5 mg | In stock | $ 397.00 | |
10 mg | In stock | $ 589.00 | |
25 mg | In stock | $ 945.00 | |
50 mg | In stock | $ 1,280.00 | |
100 mg | In stock | $ 1,730.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 443.00 |
Description | PGS-IN-1 (KME-4) is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM). |
Targets&IC50 | PGS:0.28 μM, 5-LOX:1.05 μM |
In vitro | PGS-IN-1 is the trans isomer of the synthesized α-benzulidene-γ-butyrolactone. PGS-IN-1 exhibits potent anti-inflammatory and PGS inhibitory activity with IC50 of 0.28 μM[1]. PGS-IN-1 also shows potent inhibitory activity against 5-lipoxygenase with IC50 of 1.05 μM[1]. |
Synonyms | KME-4 |
Molecular Weight | 302.41 |
Formula | C19H26O3 |
CAS No. | 102271-49-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (181.87 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PGS-IN-1 102271-49-8 GPCR/G Protein Immunology/Inflammation Metabolism Lipoxygenase Prostaglandin Receptor inhibit PGSIN1 KME-4 Inhibitor KME4 Prostaglandin E synthase PGE synthase LOX KME 4 PGS IN 1 inhibitor