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PGPC

Catalog No. T35959 CAS 89947-79-5

Synonyms: 1-Palmitoyl-2-glutaryl phosphatidylcholine

PGPC (1-Palmitoyl-2-glutaryl phosphatidylcholine) is an oxidized phospholipid and activates peroxisome proliferator-activated receptor in a concentration-dependent manner.

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PGPC, CAS 89947-79-5

Pack Size	Availability	Price/USD
500 μg	35 days	$ 65.00
1 mg	35 days	$ 123.00
5 mg	35 days	$ 480.00
10 mg	35 days	$ 830.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	PGPC (1-Palmitoyl-2-glutaryl phosphatidylcholine) is an oxidized phospholipid and activates peroxisome proliferator-activated receptor in a concentration-dependent manner.
In vitro	PGPC activates peroxisome proliferator-activated receptor in a concentration-dependent manner[3]. PGPC increases VCAM1 and E-selectin expression in human aortic endothelial cells, as well as HAEC binding by monocytes and polymorphonuclear neutrophils, in a concentration-dependent manner[4].

Synonyms	1-Palmitoyl-2-glutaryl phosphatidylcholine
Molecular Weight	609.73
Formula	C29H56NO10P
CAS No.	89947-79-5

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 20 mg/mL

DMSO: 1 mg/mL

References and Literature

1. Fruhwirth, G.O., Loidl, A., and Hermetter, A. Oxidized phospholipids: From molecular properties to disease. Biochimica et Biophysica Acta 1772, 718-736 (2007). 2. Watson, A.D., Leitinger, N., Navab, M., et al. Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo. The Journal of Biological Chemisty 272(21), 13597-13607 (1997). 3. Lee, H., Shi, W., Tontonoz, P., et al. Role for peroxisome proliferator-activated receptor α in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells. Circ. Res. 87(6), 516-521 (2000). 4. Leitinger, N., Tyner, T.R., Oslund, L., et al. Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils. Proceedings of the National Academy of Sciences of the United States of America 96(21), 12010-12015 (1999). 5. Zemski Berry, K.A., and Murphy, R.C. Phospholipid ozonation products activate the 5-lipoxygenase pathway in macrophages. Chem. Res. Toxicol. 29(8), 1355-1364 (2016). 6. Fruhwirth, G.O., Moumtzi, A., Loidl, A., et al. The oxidized phospholipids POVPC and PGPC inhibit growth and induce apoptosis in vascular smooth muscle cells. Biochim. Biophys. Acta. 1761(9), 1060-1069 (2006). 7. Mozzini, C., Frata Pasini, A., Garbin, U., et al. Increased endoplasmic reticulum stress and Nrf2 repression in peripheral blood mononuclear cells of patients with stable coronary artery disease. Free Radic. Biol. Med. 68, 178-185 (2014). 8. Gruber, F., Bicker, W., Oskolkova, O.V., et al. A simplified procedure for semi-targeted lipidomic analysis of oxidized phosphatidylcholines induced by UVA irradiation. J. Lipid. Res. 53(6), 1232-1242 (2012).

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PGPC 89947-79-5 Others 1-Palmitoyl-2-glutaryl phosphatidylcholine inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.