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PG-116800

Catalog No. T28394 CAS 291533-11-4

Synonyms: PG-530742, PGE-7113313, PGE 7113313, PG 530742

PG-116800 (PG-530742) is a matrix metalloproteinase (MMP) inhibitor. PG-116800 can be used in studies about the treatment of osteoarthritis.

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PG-116800, CAS 291533-11-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 191.00
5 mg	In stock	$ 480.00
10 mg	In stock	$ 687.00
25 mg	In stock	$ 1,080.00
50 mg	In stock	$ 1,480.00
100 mg	In stock	$ 1,990.00
500 mg	In stock	$ 3,920.00

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Purity: 100%

Purity: 98.02%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

PG-116800 (PG-530742) is a matrix metalloproteinase (MMP) inhibitor. PG-116800 can be used in studies about the treatment of osteoarthritis.

Synonyms	PG-530742, PGE-7113313, PGE 7113313, PG 530742
Molecular Weight	501.55
Formula	C24H27N3O7S
CAS No.	291533-11-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (99.69 mM)

References and Literature

1. Hudson MP, et al. Effects of selective matrix metalloproteinase inhibitor (PG-116800) to prevent ventricular remodeling after myocardial infarction: results of the PREMIER (Prevention of Myocardial Infarction Early Remodeling) trial. J Am Coll Cardiol. 2006;48(1):15-20. 2. Krzeski P, et al. Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study. Arthritis Res Ther. 2007;9(5):R109. 3. Peterson JT. The importance of estimating the therapeutic index in the development of matrix metalloproteinase inhibitors. Cardiovasc Res. 2006;69(3):677-687. 4. Rodriguez-Merchan EC. The Current Role of Disease-modifying Osteoarthritis Drugs. Arch Bone Jt Surg. 2023;11(1):11-22.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Clinical Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PG-116800 291533-11-4 Proteases/Proteasome MMP PG116800 PG530742 PGE7113313 PG-530742 PGE-7113313 PGE 7113313 PG 530742 PG 116800 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.