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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T28388 | PF-5274857 mseylate (1373615-35-0 free base) | PF5274857 HCl , PF 5274857 , PF-5274857 , PF-5274857 mesylate , PF-5274857 mseylate | |
PF-5274857 is a potent, orally active and selective inhibitor of hedgehog (Hh) signaling pathway (IC50 = 5.8 nM, Ki = 4.6 nM) . PF-5274857 effectively penetrates the blood-brain barrier and inhibits Smo activity in the b... |